The continuing evolution of targeted therapy for inflammatory skin disease

摘要: Treatment of inflammatory skin disease has evolved from non-specific suppression immune cells to increasingly precise targeting and modulation mechanisms at all levels. This led dramatic treatment successes deepened understanding the pathophysiology. The cycle in vitro studies, animal models, clinical trials, case series non-primary indications is a feedback loop that informs guides design ever better models therapeutic targets. Not only are we constantly discovering new molecules driving inflammation, have also found psoriasis other autoimmune conditions driven by distinct mediators occurring early late phases, which could be an opportunity for phase-specific or multipronged interventions. deeper our mechanistic understanding, more likely will able discover subtle strategies reprogram each patients' without having dampen eliminate their protective effects against pathogens tumors. Lastly, ongoing genomic studies might soon confirm interesting genetic markers predictive personalized medicine, earliest currently being evaluated such as HLA-Cw6 TNFAIP3. Taken together, continued evolution therapies potentially allow unprecedented form medicine not bent on silencing pathogenic mechanism, but rather aims using interventions shepherd cell swarm back correct path.