Osteoarthritis – Genetic Studies of Monogenic and Complex Forms
作者： Ana M. Valdes
DOI: 10.1016/B978-0-12-387829-8.00018-4
关键词:
摘要: Osteoarthritis (OA) is the most common joint disorder worldwide, and also associated with increased risk of mortality. OA has an important genetic basis which been explored in humans both monogenic diseases its complex form. Monogenic studies have implicated extracellular matrix genes such as AGC1 , COL2A1 COL11A1 COL11A2 MATN2 MMP-13 COMP . Genome-wide association scans candidate gene revealed complexity many contributing modestly to disease risk. The principal form belong bone morphogenetic protein family ( ASPN SMAD3 GDF5 ), potentially involved nociception MCF2L ) immune response HLA-DQB1 BTNL2 ). This list can be expected grow more genome-wide are published, whole genome sequencing applied study diseases.
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