RADIATION-INDUCED GENOMIC INSTABILITY IN THE OFFSPRING OF IRRADIATED PARENTS
作者： Yuri E. Dubrova
DOI: 10.1007/978-1-4020-6335-0_10
关键词:
摘要: So far, mutation induction in the germline of directly exposed parents has been regarded as main component genetic risk ionising radiation. However, recent data on delayed effects exposure to radiation challenge for existing paradigm. The results some publications imply that elevated rates detectable not only irradiated cells, but also their non-irradiated progeny. Here I review transgenerational instability showing radiation-induced manifests offspring, affecting and other characteristics. This paper summarises increased cancer incidence somatic tissues offspring parents. possible mechanisms are discussed.
springer.com
sci-hub.st 参考文章(89)
L. A. Fomenko, G. V. Vasiljeva, V. G. Bezlepkin, Elevated Micronucleus Frequency in Bone Marrow Erythrocytes in the Progeny of Male Mice Exposed to Chronic Low-Dose Gamma Irradiation Biology Bulletin of the Russian Academy of Sciences. ,vol. 28, pp. 350- 353 ,(2001) , 10.1023/A:1016614922139
Wolfram Siede, Graham C. Walker, Errol C. Friedberg, DNA Repair and Mutagenesis ,(2006)
Peter A. Jones, Stephen B. Baylin, The fundamental role of epigenetic events in cancer Nature Reviews Genetics. ,vol. 3, pp. 415- 428 ,(2002) , 10.1038/NRG816
Katharine P. Hoyes, Brian I. Lord, Christine McCann, Jolyon H. Hendry, Ian D. Morris, Transgenerational Effects of Preconception Paternal Contamination with 55Fe Radiation Research. ,vol. 156, pp. 488- 494 ,(2001) , 10.1667/0033-7587(2001)156[0488:TEOPPC]2.0.CO;2
Wafa Harrouk, Alexis Codrington, Robert Vinson, Bernard Robaire, Barbara F Hales, Paternal exposure to cyclophosphamide induces DNA damage and alters the expression of DNA repair genes in the rat preimplantation embryo. Mutation Research-dna Repair. ,vol. 461, pp. 229- 241 ,(2000) , 10.1016/S0921-8777(00)00053-7
Ruth C. Barber, Laurent Miccoli, Paul P.W. van Buul, Karen L.-A. Burr, Annemarie van Duyn-Goedhart, Jaime F. Angulo, Yuri E. Dubrova, Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutation Research. ,vol. 554, pp. 287- 295 ,(2004) , 10.1016/J.MRFMMM.2004.05.003
B. Ponnaiya, M. N. Cornforth, R. L. Ullrich, Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white Radiation Research. ,vol. 147, pp. 121- 125 ,(1997) , 10.2307/3579411
V.S. Turusov, T.V. Nikonova, Yu.D. Parfenov, Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant. Cancer Letters. ,vol. 55, pp. 227- 231 ,(1990) , 10.1016/0304-3835(90)90123-F
Yuri E. Dubrova, Mark Plumb, Julia Brown, Emma Boulton, Dudley Goodhead, Alec J. Jeffreys, Induction of minisatellite mutations in the mouse germline by low-dose chronic exposure to γ-radiation and fission neutrons Mutation Research. ,vol. 453, pp. 17- 24 ,(2000) , 10.1016/S0027-5107(00)00068-3
Taesei Nomura, X-ray-induced germ-line mutation leading to tumors. Its manifestation in mice given urethane post-natally. Mutation Research Letters. ,vol. 121, pp. 59- 65 ,(1983) , 10.1016/0165-7992(83)90087-8