Treatment of aplastic anaemia by antilymphocyte globulin with or without marrow infusion.

摘要: Forty-one patients, suffering from severe aplastic anaemia were treated either with ALG alone (27 patients) or followed by infusion of allogeneic bone marrow (14 patients). Eighteen patients (67 per cent) are presently alive after at over 100 to 550 days. Fourteen (52 showed sustained improvement haematopoiesis, two without change, one recovered autologous haematopoiesis cyclophosphamide conditioning and transfusion HLA identical is lost follow-up. Eight (57 currently haplotype self-sustaining 200 days four a half years. No lethal complications occurred none the infusions led permanent engraftment graft-versus-host disease. The mechanism action not known, but our results support hypothesis that unspecified autoimmune reactions block normal outgrowth haematopoietic precursor cells in substantial number anaemia. This therapeutic approach seems offer good chances survival, especially for those who do have an sibling. Its value should be further investigated.