Fluoropyrimidines as Antifolate Drugs

摘要: 5 Fluorouracil (5FU) is a rationally designed antineoplastic agent (1,2) with distinct antifolate and antipyrimidine properties. 5FU usually given in combination other agents for the treatment of various types cancer (3–11) such as cancers gas-trointestinal tract, breast cancer, head neck cancer. For combinations leucov-orin (LV) objective response rates between 20 40% have been achieved randomized trials patients colorectal which means that more than 60% tumors are still resistant will thereafter develop resistance. This resistance can be multifactorial (Table 1), related to either or prop-erties drug. also implies many an intrinsic 5FU, since almost all show relapse, this remaining acquired occur. Unfortunately mechanism modulation-re-sistance has hardly addressed most these studies.