Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.
作者： Phillip L. Van , Kyong-Wook Yim , Dong-Yan Jin , George Dapolito , Akihiro Kurimasa
DOI: 10.1128/JVI.75.1.396-407.2001
关键词:
摘要: Recent evidence from several investigators suggest that the human T-cell leukemia virus type 1 Tax oncoprotein represses transcriptional activity of tumor suppressor protein, p53. An examination published findings reveals serious controversy as to mechanism(s) utilized by inhibit p53 and whether same mechanism is used in adherent suspension cells. Here, we have investigated Tax-p53 interaction simultaneously epithelial (HeLa Saos) T-lymphocyte (Jurkat) Our results indicate through CREB/CREB-binding protein (CBP), but not NF-κB, pathway needed repress all tested cell lines. However, did find while CBP binding necessary, it sufficient for inhibiting function. Based on knockout studies, correlated a strong genetic requirement ATM, kinase-dependent DNA, conferring Tax-p53-repressive phenotype.
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