Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
作者： Patricia J. Keely , John K. Westwick , Ian P. Whitehead , Channing J. Der , Leslie V. Parise
DOI: 10.1038/37656
关键词:
摘要: Transformation of mammary epithelial cells into invasive carcinoma results in alterations their integrin-mediated responses to the extracellular matrix, including a loss normal polarization and differentiation, switch more motile, phenotype. Changes actin cytoskeleton associated with this suggest that small GTPases Cdc42 Rac, which regulate organization, might modulate motility invasion. However, role Rac1 cells, especially respect events, has not been well characterized. Here we show activation disrupts collagenous promotes This does require PAK, JNK, p70 S6 kinase, or Rho, but instead requires phosphatidylinositol-3-OH kinase (PI(3)K). Further, direct PI(3)K is sufficient disrupt induce cell inhibition also structures, suggesting by alters leading increased invasiveness.
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