Scaling toxicity from laboratory animals to people: an example with nitrogen dioxide.

摘要: Published data on the toxicity of nitrogen dioxide (as a model compound) from five laboratory animal species were utilized to scale relationship dose and toxic effect human species. A minute volume inspired air was used as metabolic scaling factor, predicting median lethality during time exposure 174 ppm NO 2 for 1‐h people. This work demonstrates method effects in people when only animals exist. It also shows value planning toxicology studies that utilize several species, so their may be applied forecasting condition.