Role and Regulation of β-Catenin Signaling During Physiological Liver Growth

摘要: Wnt/β-catenin signaling plays key roles not only during development but also in adult tissue homeostasis. This is evident liver biology where many temporal of β-catenin have been identified hepatic development, where, progenitors or hepatoblasts, it a determinant proliferation and eventually differentiation to mature hepatocytes, while playing an important role bile duct β-Catenin cascade mostly quiescent hepatocytes except the centrizonal region lobule. small rim around central vein show constitutive activation that turn regulates expression genes whose products play ammonia xenobiotic metabolism. Intriguingly, can undergo after acute loss secondary surgical toxicant insult. Such this progrowth protein observed as nuclear translocation formation its complex with T-cell factor (TCF) family transcription factors. Expression cyclin-D1, inducer transition from G1 S phase cell cycle, regulated by β-catenin-TCF complex. Thus, absolutely critical normal regeneration process shown studies several models across various species. In current review, regulation metabolic zonation basal liver, will be discussed. addition, probability therapeutically regulating activity possible future treatment strategy for insufficiency