Protein kinase Cε: multiple roles in the function of, and signaling mediated by, the cytoskeleton

作者: Yoshiko Akita

DOI: 10.1111/J.1742-4658.2008.06557.X

关键词:

摘要: Recent studies have established essential roles of protein kinase Ce in signaling pathways controlling various functions microfilaments and intermediate filaments by modulating multiple cytoskeletal proteins. This review summarizes recent progress our understanding the filaments, with a focus mainly on cell–matrix cell–cell interactions, migrations contraction, addition to its relevance development several diseases, such as malignant tumors or cardiac disease.

参考文章(56)
Gautam Bhave, Robert W Gereau, Growing Pains Neuron. ,vol. 39, pp. 577- 579 ,(2003) , 10.1016/S0896-6273(03)00500-2
Hiromichi Yonekawa, Yoshiko Akita, Protein kinase Cε: the mitochondria-mediated signaling pathway FEBS Journal. ,vol. 275, pp. 4005- 4013 ,(2008) , 10.1111/J.1742-4658.2008.06558.X
Jolanda van Hengel, Lionel Gohon, Erik Bruyneel, Stefan Vermeulen, Maria Cornelissen, Marc Mareel, Frans van Roy, Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes. Journal of Cell Biology. ,vol. 137, pp. 1103- 1116 ,(1997) , 10.1083/JCB.137.5.1103
Yoshiko Akita, Hiroshi Kawasaki, Shinobu Imajoh-Ohmi, Hiroyuki Fukuda, Shigeo Ohno, Hisashi Hirano, Yoshitaka Ono, Hiromich Yonekawa, Protein kinase C ε phosphorylates keratin 8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing hormone FEBS Journal. ,vol. 274, pp. 3270- 3285 ,(2007) , 10.1111/J.1742-4658.2007.05853.X
Ralph Knöll, Masahiko Hoshijima, Hal M. Hoffman, Veronika Person, Ilka Lorenzen-Schmidt, Marie-Louise Bang, Takeharu Hayashi, Nobuyuki Shiga, Hideo Yasukawa, Wolfgang Schaper, William McKenna, Mitsuhiro Yokoyama, Nicholas J. Schork, Jeffrey H. Omens, Andrew D. McCulloch, Akinori Kimura, Carol C. Gregorio, Wolfgang Poller, Jutta Schaper, Heinz P. Schultheiss, Kenneth R. Chien, The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy Cell. ,vol. 111, pp. 943- 955 ,(2002) , 10.1016/S0092-8674(02)01226-6
Michael Csukai, Che-Hong Chen, Maria Antonietta De Matteis, Daria Mochly-Rosen, The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε Journal of Biological Chemistry. ,vol. 272, pp. 29200- 29206 ,(1997) , 10.1074/JBC.272.46.29200
Daqing Wu, Chittam U Thakore, Ginger G Wescott, James A McCubrey, David M Terrian, Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. Oncogene. ,vol. 23, pp. 8659- 8672 ,(2004) , 10.1038/SJ.ONC.1207900
Masaki Fukata, Takashi Watanabe, Jun Noritake, Masato Nakagawa, Masaki Yamaga, Shinya Kuroda, Yoshiharu Matsuura, Akihiro Iwamatsu, Franck Perez, Kozo Kaibuchi, Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170 Cell. ,vol. 109, pp. 873- 885 ,(2002) , 10.1016/S0092-8674(02)00800-0
Heng-Fu Bu, Xiu-Li Zuo, Xiao Wang, Michael A. Ensslin, Vjola Koti, Wei Hsueh, Adam S. Raymond, Barry D. Shur, Xiao-Di Tan, Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. Journal of Clinical Investigation. ,vol. 117, pp. 3673- 3683 ,(2007) , 10.1172/JCI31841