Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study

摘要: Previous research has revealed that glucose and fructose ingestion differentially modulate release of satiation hormones. Recent studies have begun to elucidate brain-gut interactions with neuroimaging approaches such as magnetic resonance imaging (MRI), but the neural mechanism underlying different behavioral physiological effects are unclear. In this paper, we used resting state functional MRI explore whether acute also induced dissociable in system. Using a cross-over, double-blind, placebo-controlled design, compared connectivity (rsFC) strengths within basal ganglia/limbic network 12 healthy lean males. Each subject was administered fructose, placebo on three separate occasions. Subsequent correlation analysis examine relations between rsFC findings plasma concentrations hormones subjective feelings appetite. Glucose significantly greater elevations glucose, insulin, GLP-1 GIP, while fullness increased prospective food consumption decreased relative fructose. Furthermore, left caudatus putamen, precuneus lingual gyrus more than whereas network, amygdala, hippocampus, right parahippocampus, orbitofrontal cortex precentral glucose. Moreover, after positively correlated glucose-induced increase insulin. Our suggest induce which probably mediated by insulin levels. A larger study would be recommended order confirm these findings.