Distribution and ultrastructural localization of a receptor for pituitary adenylate cyclase activating polypeptide and its mRNA in the rat retina.
作者： Tamotsu Seki , Seiji Shioda , Dai Ogino , Yasumitsu Nakai , Akira Arimura
DOI: 10.1016/S0304-3940(97)00869-0
关键词:
摘要: Localization and gene expression of pituitary adenylate cyclase activating polypeptide receptor (PACAPR) in the rat retina were studied by immunocytochemistry situ hybridization, respectively. Antisera raised against a synthetic peptide that corresponds to carboxy-terminal cytoplasmic domain which is found all subtypes PACAPR. Strong PACAPR mRNA PACAPR-like immunoreactivity (PACAPR-LI) detected ganglion cells, amacrine inner plexiform layer. PACAPR-LI appeared be concentrated predominantly neuronal perikarya processes. At ultrastructural level, strong immunostaining for was visible plasma membranes, rough endoplasmic reticulum matrix neurons. This study provides basis better understanding functions PACAP retina.
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