Antifibrillatory effects of clofilium in the rabbit isolated heart.
作者： Gregory S. Friedrichs , Liguo Chi , Alysia L. Green , Benedict R. Lucchesi
DOI: 10.1111/J.1476-5381.1994.TB16195.X
关键词:
摘要: 1. This study was designed to determine whether clofilium exhibits antifibrillatory activity in a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) Langendorff-perfused hearts. 2. Ten minutes after exposure vehicle or (0.1, 1.0 and 10.0 microM), hearts were exposed (1.25 then subjected 12 min hypoxia reoxygenated. Onset VF recorded. Additional groups pretreated with UK-68,798 (1.0, 3.0 delayed rectifier channel blocker, 5-hydroxydecanoate (10 known ATP-dependent K+ an identical protocol. 3. Clofilium decreased the incidence concentration-dependent manner; 7/9 control developed vs 1/9 (P = 0.007, Fisher's Exact) treated microM clofilium. In addition, protected from VF, while pretreatment did not. 4. separate group hearts, electrically-induced converted sinus rhythm 10/11 introduced as bolus. 5. is capable preventing rabbit isolated heart manner. We have data suggest that ability attenuate effects pinacidil+hypoxia our may include blockade metabolically active channels, i.e., KATP (glibenclamide-sensitive) channel.
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R A Burges, J E Arrowsmith, P E Cross, K J Blackburn, M Gwilt, A J Higgins, H W Dalrymple, UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. Journal of Pharmacology and Experimental Therapeutics. ,vol. 256, pp. 318- 324 ,(1991)
E Carmeliet, Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. Journal of Pharmacology and Experimental Therapeutics. ,vol. 262, pp. 809- 817 ,(1992)
Hidenari Sakuta, Koichi Okamoto, Yasuhiro Watanabe, Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide-sensitive K+ currents in Xenopus oocytes. British Journal of Pharmacology. ,vol. 109, pp. 866- 872 ,(1993) , 10.1111/J.1476-5381.1993.TB13655.X
Peter R. Kowey, Ted D. Friehling, Kathleen M. O'Connor, Lewis Wetstein, Gerald J. Kelliher, The effect of bretylium and clofilium on dispersion of refractoriness and vulnerability to ventricular fibrillation in the ischemic feline heart. American Heart Journal. ,vol. 110, pp. 363- 370 ,(1985) , 10.1016/0002-8703(85)90157-7
Liguo Chi, Dun-Xue Mu, Edward M. Driscoll, Benedict R. Lucchesi, Antiarrhythmic and electrophysiologic actions of CK-3579 and sematilide in a conscious canine model of sudden coronary death. Journal of Cardiovascular Pharmacology. ,vol. 16, pp. 312- 324 ,(1990) , 10.1097/00005344-199008000-00019
Marvin B. Bacaner, Treatment of ventricular fibrillation and other acute arrhythmias with bretylium tosylate. American Journal of Cardiology. ,vol. 21, pp. 530- 543 ,(1968) , 10.1016/0002-9149(68)90286-5
Helen L. Reeve, Chris Peers, Blockade of delayed rectifier K+ currents in neuroblastoma × glioma hybrid (NG 108–15) cells by clofilium, a class III antidysrhythmic agent British Journal of Pharmacology. ,vol. 105, pp. 458- 462 ,(1992) , 10.1111/J.1476-5381.1992.TB14275.X
Liguo Chi, Andrew C. G. Uprichard, Benedict R. Lucchesi, Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death. Journal of Cardiovascular Pharmacology. ,vol. 15, pp. 452- 464 ,(1990) , 10.1097/00005344-199003000-00016
L Carlsson, C Abrahamsson, L Drews, G Duker, Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Circulation. ,vol. 85, pp. 1491- 1500 ,(1992) , 10.1161/01.CIR.85.4.1491
Cynthia L. Martin, Kevin Chinn, Pinacidil opens ATP-dependent K+ channels in cardiac myocytes in an ATP- and temperature-dependent manner. Journal of Cardiovascular Pharmacology. ,vol. 15, pp. 510- 514 ,(1990) , 10.1097/00005344-199003000-00024