Facile Synthetic Route for Surface-Functionalized Magnetic Nanoparticles: Cell Labeling and Magnetic Resonance Imaging Studies
作者： Hyun Jung Chung , Haeshin Lee , Ki Hyun Bae , Yuhan Lee , Jongnam Park
DOI: 10.1021/NN201198F
关键词:
摘要: Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need be improved due potential aggregation, reduction of superparamagnetism, and the use toxic reagents. Herein, we present a facile strategy for transfer dispersion organic-synthesized IONPs using only polyethylene glycol (PEG), biocompatible polymer. A library PEG derivatives was screened, it determined that amine-functionalized six-armed PEG, 6(PEG-NH(2)), most effective agent. The 6(PEG-NH(2))-modified (IONP-6PEG) were stable after extensive washing, exhibited high could used as platform material secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized hyaluronic acid (IONP-6PEG-HA) shown specifically label mesenchymal stem cells demonstrate MR contrast r(2) relaxivity (442.7 s(-1)mM(-1)) compared commercially Feridex (182.1 s(-1)mM(-1)).
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