Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori.

摘要: The effects of Helicobacter pylori infection on gastric acid secretion has not been clarified. aim this study was to elucidate the H. juice pH in relation gene expression interleukin-1beta (IL-1beta), which is reported inhibit secretion. Gastric and serum gastrin levels were measured patients with peptic ulcer disease. amount IL-1beta mRNA fundic gland mucosa also by a competitive reverse transcription-polymerase chain reaction method. These parameters determined before after treatment lansoprazole amoxicillin. Before significant positive observed between pH. After decreases mRNA, pH, eradication pylori, whereas no changes without eradication. results suggest that induces suppresses secretion, resulting increases levels. Eradication induction, an increase acidity normalization