DOSE-RESPONSE RELATION BETWEEN ARSENIC CONCENTRATION IN WELL WATER AND MORTALITY FROM CANCERS AND VASCULAR DISEASES

摘要: Age-adjusted mortality rates were analyzed to examine the dose-response relation between ingested arsenic levels and risk of cancers vascular diseases among residents in endemic area blackfoot disease, a unique peripheral disease associated with long-term exposure high-arsenic artesian well water confined southwestern coast Taiwan. The determined 1964-1966 available 42 villages study area, while population data during 1973-1986 obtained from local household registration offices Taiwan Provincial Department Health. various by sex calculated using 1976 world as standard population. A significant was observed bladder, kidney, skin, lung both males females, prostate liver males. However, there no association for nasopharynx, esophagus, stomach, colon, uterine cervix, leukemia. Arsenic also cardiovascular pattern, but not cerebrovascular accidents. dual effect on carcinogenesis arteriosclerosismore » interrelation these two pathogenic mechanisms deserve more intensive study.« less