Interleukin-16 in a mouse model of allergic asthma

摘要: Allergic asthma is a disease which affects an increasing number of people. Patients with this illness suffer from variable airflow obstruction and increased airway responsiveness to variety stimuli. Furthermore, inflammatory response in the lungs occurs, accompanied by enhanced mucus production (10). In serum these patients levels IgE antibodies can be detected (reviewed 238, 239). Currently, several different drugs are available for people who asthma. These medicines include corticosteroids, b2-agonists, leukotriene antagonists phosphodiesterase inhibitors (240-244). Corticosteroids most effective used drug at moment treatment reduce component hyperresponsiveness (245). However, corticosteroids not very selective affect whole range non-inflammatory cells (246-248). More importantly, all that allergic do cure but only clinical symptoms disorder. Therefore, current research focused on development strategies treat asthmatics more causal level their illness. It now widely accepted T-helper type 2 (Th2) lymphocytes play role (10, 249, 250). Th2 produce limited set cytokines including interleukin-3 (IL3), IL4, IL5, IL9, IL10 IL13. Both human asthmatic murine models subsets have been (8, 9) it extensively documented produced crucial symptoms. New could therefore aimed specifically targeting T cell subset or (18, 251, 252).