Short-Dwell Ethanol Lock Therapy in Children Is Associated With Increased Clearance of Central Line–Associated Bloodstream Infections
作者： Eric J. McGrath , Ralph Salloum , Xinguang Chen , Yifan Jiang , Kathrina Boldt-MacDonald
关键词:
摘要: Background. Central line–associated bloodstream infection (CLABSI) is a known complication of central line use. Salvage infected lines with ethanol lock therapy (ELT) systemic antimicrobials may be an alternative treatment option in children. Methods. Retrospective review was performed children CLASBI who underwent short-dwell ELT (70% ethanol, 4- to 25-hour dwell times ≤3 days) from January 1, 2007 July 15, 2009. Results. A total 59 patients, aged 2 months 19 years (mean ± SD = 6.3 6.1 years) 80 episodes CLABSI were included. The eradication rate 86% (69/80 episodes; 95% confidence interval [CI] 78%, 94%), significantly greater than 50% (Z 2.35, P < .05), the estimated clearance using alone. Overall retention 78% (60/77 episodes, CI 69%, 87%). well tolerated. Conclusions. These findings suggest potential benefit combine...
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