LncRNA HOTAIR acts a competing endogenous RNA to control the expression of notch3 via sponging miR-613 in pancreatic cancer.
作者： Huihua Cai , Jie Yao , Yong An , Xuemin Chen , Weibo Chen
DOI: 10.18632/ONCOTARGET.16462
关键词:
摘要: Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Though studies have implicated roles microRNAs in pancreatic progression, little known about role miR-613 cancer. In present study, expression was down-regulated tissues and cell lines. Down-regulation positively correlated tumor differentiation, advanced TNM stage, nodal metastasis shorter overall survival patients Overexpression suppressed proliferation, invasion migration, induced apoptosis cycle arrest at G0/G1 phase cells. Bioinformatics analysis, luciferase reporter assay rescue experiments showed that notch3 direct target miR-613. MiR-613 inversely tissues. The long non-coding RNA, HOX transcript antisense RNA (HOTAIR) up-regulated both lines, HOTAIR via functioning as competing endogenous RNA. vivo stable overexpression or knock-down growth also reduced notch3. conclusion, these results suggest functions to regulate sponging
impactjournals.com参考文章(39)
Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl, MicroRNAs in Human Cancer Advances in Experimental Medicine and Biology. ,vol. 774, pp. 1- 20 ,(2013) , 10.1007/978-94-007-5590-1_1
Chong-yun Xing, Xiao-qu Hu, Fei-yan Xie, Zhi-jie Yu, Hai-ying Li, Bin-Zhou, Jian-bo Wu, Li-yuan Tang, Shen-meng Gao, Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia FEBS Letters. ,vol. 589, pp. 1981- 1987 ,(2015) , 10.1016/J.FEBSLET.2015.04.061
Benjamin Purow, Notch inhibition as a promising new approach to cancer therapy. Advances in Experimental Medicine and Biology. ,vol. 727, pp. 305- 319 ,(2012) , 10.1007/978-1-4614-0899-4_23
Shanghui Guan, Cong Wang, Xuan Chen, Bowen Liu, Bingxu Tan, Fang Liu, Ding Wang, Lihui Han, Lu Wang, Xiaochen Huang, Jiangfeng Wang, Bin Yao, Jialei Shi, Pengxiang Chen, Effat Un Nesa, Qingxu Song, Yufeng Cheng, MiR-613: a novel diagnostic and prognostic biomarker for patients with esophageal squamous cell carcinoma Tumor Biology. ,vol. 37, pp. 4383- 4391 ,(2016) , 10.1007/S13277-015-4271-8
Hua Liu, Xuan-Fu Xu, Yan Zhao, Mao-Chun Tang, Ying-Qun Zhou, Jie Lu, Feng-Hou Gao, MicroRNA-191 promotes pancreatic cancer progression by targeting USP10 Tumor Biology. ,vol. 35, pp. 12157- 12163 ,(2014) , 10.1007/S13277-014-2521-9
Christopher D. Mann, Christopher Bastianpillai, Christopher P. Neal, Muhammad M. Masood, Donald J. L. Jones, Friederike Teichert, Rajinder Singh, Elena Karpova, David P. Berry, Margaret M. Manson, Notch3 and Hey-1 as Prognostic Biomarkers in Pancreatic Adenocarcinoma PLoS ONE. ,vol. 7, pp. e51119- ,(2012) , 10.1371/JOURNAL.PONE.0051119
Wook Kim, Yu-Kyong Shin, Byung-Joon Kim, Josephine M. Egan, Notch signaling in pancreatic endocrine cell and diabetes Biochemical and Biophysical Research Communications. ,vol. 392, pp. 247- 251 ,(2010) , 10.1016/J.BBRC.2009.12.115
Jun Yao, Cuijuan Qian, Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway Medical Oncology. ,vol. 27, pp. 1017- 1022 ,(2010) , 10.1007/S12032-009-9326-5
Wan-Ching Yen, Marcus M Fischer, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, William R Henner, Rene Meisner, Aaron Sato, Jalpa Shah, Tracy Tang, Breanna Wallace, Min Wang, Chun Zhang, Ann M Kapoun, John Lewicki, Austin Gurney, Timothy Hoey, None, Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency Clinical Cancer Research. ,vol. 21, pp. 2084- 2095 ,(2015) , 10.1158/1078-0432.CCR-14-2808
Ryunosuke Kogo, Teppei Shimamura, Koshi Mimori, Kohichi Kawahara, Seiya Imoto, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Akira Suzuki, Shizuo Komune, Satoru Miyano, Masaki Mori, Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers Cancer Research. ,vol. 71, pp. 6320- 6326 ,(2011) , 10.1158/0008-5472.CAN-11-1021