Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts
作者： Bruno A. Silva , Federico Ferreres , João O. Malva , Alberto C.P. Dias
DOI: 10.1016/J.FOODCHEM.2004.03.049
关键词:
摘要: Abstract The antioxidant potentials of a total ethanolic extract Hypericum perforatum (TE) and fractions were evaluated correlated with their phenolic contents. extracts fully characterised by HPLC–DAD–MS–MS. Kaempferol 3-rutinoside rutin-acetyl identified for the first time in TE extracts. free radical-scavenging properties (EC50=21 μg dwb/ml) studied using DPPH. Fractions containing flavonoids and/or caffeoylquinic acids found to be main contributors activity TE. Lipid peroxidation, induced ascorbate/Fe2+, was significantly reduced presence (EC50=26 acids. fraction flavonoid aglycones responsible major part protection against lipid peroxidation. Hypericins hyperforins made no significant contributions Human consumption H. or could beneficial.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(43)
A. C. P. Dias, M. F. Ferreira, Production of Phenolics by in Vitro Cultures of Hypericum perforatum: A Case Study Springer Netherlands. pp. 367- 374 ,(2002) , 10.1007/978-94-015-9876-7_36
Ana P. Silva, Arsélio P. Carvalho, Caetana M. Carvalho, João O. Malva, Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. Journal of Neurochemistry. ,vol. 79, pp. 286- 296 ,(2008) , 10.1046/J.1471-4159.2001.00560.X
C.A.J. Erdelmeier, E. Koch, R. Hoerr, Hypericum Perforatum - St. John's Wort Chemical, Pharmacological and Clinical Aspects Studies in natural products chemistry. ,vol. 22, pp. 643- 716 ,(2000) , 10.1016/S1572-5995(00)80037-X
Dong-Hoon Hyun, Moon-Hee Lee, Barry Halliwell, Peter Jenner, Proteasomal dysfunction induced by 4‐hydroxy‐2,3‐trans‐nonenal, an end‐product of lipid peroxidation: a mechanism contributing to neurodegeneration? Journal of Neurochemistry. ,vol. 83, pp. 360- 370 ,(2002) , 10.1046/J.1471-4159.2002.01125.X
Christian Behl, Bernd Moosmann, Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach2 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal. Free Radical Biology and Medicine. ,vol. 33, pp. 182- 191 ,(2002) , 10.1016/S0891-5849(02)00883-3
Kuresh A. Youdim, Michael S. Dobbie, Gunter Kuhnle, Anna R. Proteggente, N. Joan Abbott, Catherine Rice-Evans, Interaction between flavonoids and the blood-brain barrier: in vitro studies. Journal of Neurochemistry. ,vol. 85, pp. 180- 192 ,(2003) , 10.1046/J.1471-4159.2003.01652.X
Irwin Fridovich, Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters Journal of Biological Chemistry. ,vol. 272, pp. 18515- 18517 ,(1997) , 10.1074/JBC.272.30.18515
Catherine Rice-Evans, Nicholas Miller, George Paganga, Antioxidant properties of phenolic compounds Trends in Plant Science. ,vol. 2, pp. 152- 159 ,(1997) , 10.1016/S1360-1385(97)01018-2
Guido Jürgenliemk, Adolf Nahrstedt, Phenolic compounds from Hypericum perforatum. Planta Medica. ,vol. 68, pp. 88- 91 ,(2002) , 10.1055/S-2002-20053
Filip Cuyckens, Raoul Rozenberg, Edmond de Hoffmann, Magda Claeys, Structure characterization of flavonoid O-diglycosides by positive and negative nano-electrospray ionization ion trap mass spectrometry Journal of Mass Spectrometry. ,vol. 36, pp. 1203- 1210 ,(2001) , 10.1002/JMS.224