Chemoprevention of lung cancer: current status and future prospects.

摘要: Lung cancer is the leading cause of death in United States. The current mainstays lung therapy are surgery, radiation and chemotherapy. These interventions have produced slight declines mortality rates last 5 years however, it appears unlikely that marked improvements will occur near future. This grim overview argues strongly for new, emerging approaches controlling this disease. Chemoprevention use specific natural or synthetic substances with objective reversing, suppressing preventing carcinogenic progression to invasive cancer. Whether primary, secondary tertiary settings, prevention has highest potential improve dismal statistics associated Several randomized clinical translational chemoprevention trials been conducted. All so far either neutral harmful primary endpoint results showing was not prevented by alpha-tocopheral, beta-carotene, retinal, retinyl palmitate, N-acetylcysteine isotretinoin smokers. Secondary supporting treatment 'never' former smokers data from involving selenium vitamin E encouraging offer a promising direction future study. Other areas promise study include molecular markers risk drug activity, targeting study, improved imaging techniques new delivery systems.