A two-locus forensic match probability for subdivided populations.

摘要: A two-locus match probability is presented that incorporates the effects of within-subpopulation inbreeding (consanguinity) in addition to population subdivision. The usual practice calculating multi-locus probabilities as product single-locus assumes independence between loci. There are a number genetics phenomena can violate this assumption: consanguinity, which increases homozygosity at all loci simultaneously, gametic disequilibrium will introduce dependence into DNA profiles. However, forensics latter problem usually addressed part by careful choice unlinked Hence, conventional, we assume equilibrium here, and focus instead on between-locus due consanguinity. resulting formulae an extension existing methods literature, shown be more conservative than these case double homozygote matches. For profiles involving one or heterozygous genotypes, results similar to, smaller than, approaches.