Antibiotic Use and the Risk of Lung Cancer

摘要: Antibiotic use has been associated with an increased risk of cancer in epidemiologic studies. We evaluated the association between antibiotic and primary lung by conducting a prospective case-control study nested cohort subjects who were 40 to 84 years old 1995 2004, at least 2 enrollment The Health Improvement Network. There 4,336 cases cancer. A random sample 10,000 controls was frequency matched for age, sex, calendar year diagnosis. exposure measured total number prescriptions cumulative days on antibiotics since enrollment. discounted 1 before date Relative risks (RR) 95% confidence intervals (95% CI) estimated using conditional logistic regression. Smoking, chronic obstructive pulmonary disease, respiratory infections, body mass index, health care utilization introduced model. Compared no prescription index date, crude RR 2.52 CI, 2.25-2.83) among those received 10 or more prescriptions. corresponding 1.31 1.10-1.57) upon adjustment confounders. used directed acyclic graphs illustrate that observed higher users may be due infections patients subclinical shared causes infections. Current evidence is insufficient support refute carcinogenic effect antibiotics.