Tissue distribution of intravenously administrated hydroxyapatite nanoparticles labeled with 125I.

摘要: Hydroxyapatite nanoparticles (HANPs) have been developed for biomedical use due to its extraordinary properties. However, the side effects of HANPs on human body also concerned, especially in vivo. Now it is still unknown how about distribution and biobehavior vivo is, though it's very important application biosystem. This study was establish a new method 125I radiolabeling at 80 nm, investigate long-term tissue quantitatively after intravenously administrated labeled with subcellular liver spleen by TEM. The results indicated had high stability vitro, could accumulate mainly decrease time dependent manner, but retain more than 28 days. stagnation most probably attribute endocytosis macrophages these tissues. implied radioactive iodine labeling an effective sensitive tracing analyzing NPs Liver should be main target organ reached when were injected into circulation system. Because stay over one month, biosafety shouldn't neglected.