High Pressure Liquid Chromatographic Microassay for Simultaneous Measurement of Doxapram and its Metabolites in Premature Newborn Infants
作者： J. V. Aranda , K. Beharry , J. Rex , N. Linder , P. Blanchard
DOI: 10.1080/01483918808076774
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摘要: Abstract A simple, specific, rapid and sensitive high pressure liquid chromatographic microassay is described for the simultaneous measurement of doxapram its metabolites. Doxapram appears rapidly metabolized to ketodoxapram in premature newborn infants with apnea. Therapeutic drug monitoring metabolites warranted during therapy neonatal
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