Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man

摘要: Blockade of cardiac autonomic nervous activity by an intravenous injection 0.2 mg/kg propranolol and 0.04 atropine was used with catheterization to study intrinsic function in 47 patients normal hearts known graded myocardial disease. After blockade, significant hemodynamic abnormalities became apparent at rest the majority disease, many whom had control findings. This occurred partly through a reduction range rest, changes associated disease: after diseased stroke volumes, but beat more slowly, higher left ventricular filling pressures. The heart rate blockade fixed; this defined as (IHR); it ranged from 57 126 beats/min different patients. Both IHR end-diastolic pressure were sensitively quantitatively related severity When, arterial raised angiotensin, unchanged; maintained their volume increased work; less well work unchanged or fell. Abnormal responses corresponded abnormal rest. In significantly each available index function. Other studies animals have shown that is closely contractility certain forms experimental failure. An analogous relationship existing between disease suggested explanation for IHR/ventricular study. If so, may prove valuable man, since can be measured simply safely clinical practice.