Effect of Solanum erianthum aqueous leaf extract on Plasmodium berghei in mice.

摘要: The aqueous leaf extract of Solanum erianthum collected in May was administered orally to albino Swiss mice infected with Plasmodium berghei berghei. schizontocidal activity on early infection assessed by administering the S. erianthum, chloroquine, or distilled water as single daily dose from day for 4 days. Microscopic examination made fifth all mice, showed producing a dose-related effect, highest having chloroquine equivalent 1.7 mg/kg. residual this it 3 days prior inoculation parasites. Seventy-two hours after infecting microscopic blood smears mice. produced activity. and 1.2 mg/kg pyrimethamine 78.9 80.5% chemosuppression, respectively. Its effect established studied drugs 72 h 5 level parasitaemia daily. results show that did not produce any significant suppression infection. observations are interesting promising view fact crude used also because controversy exists its usefulness an anti-malarial agent.