Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step multicomponent reaction followed by a S-alkylation.

摘要: A sequential one-pot two-step protocol for microwave-assisted synthesis of Hantzsch-type hexa-substituted 1,4-dihydropyridines has been developed. The three-component reactions β-aroylthioamides with aldehydes and acetonitrile derivatives produce the intermediates in situ followed by a S-alkylation to afford 1,4-dihydropyridines. reaction presumably proceeds via Knoevenagel condensation−Michael addition−cyclocondensation−rearrangement−SN2 sequence. Target compounds were obtained high yields simply purified recrystallization. novel method is complementary classical Hantzsch that it well-suited preparation