Markers for amyotrophic lateral sclerosis (als) and presymptomatic alzheimer's desease (psad)
作者： John David Aitchison , Leslie Rae Miller , Samuel Anthony Danziger , Jennifer Joy Smith
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摘要: Methods to detect amyotrophic lateral sclerosis (ALS) or presymptomatic Alzheimer's disease (PSAD) using an indicator cell assay platform (iCAP) in a test subject are described. Specifically, the disclosure provides method comprising contacting biological fluid of said with cells and assessing for level expression exon CKIgamma2 that encodes C-terminal palmitoylated region CKIgamma2, determine probability is afflicted (ALS). Further disclosed methods pan neuronal populations glutamatergic (and/or GABAergic) neurons presence symptomatic subject.
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