Biotransformation of 8:2 polyfluoroalkyl phosphate diester in gilthead bream (Sparus aurata).

摘要: Polyfluoroalkyl phosphate esters (PAPs) are high production volume surfactants used in the food contact paper and packaging industry. PAPs may transform to persistent perfluoroalkyl carboxylic acids (PFCAs) under biotic conditions, but little is known about their fate behavior aquatic organisms. Here we report for first time on uptake, tissue distribution, biotransformation of 8:2 polyfluoroalkyl diester (8:2 diPAP) fish. Gilt-head bream (Sparus aurata) were dosed via diet diPAP at 29μg/g) 7days, during which its transformation products monitored plasma, liver, muscle, gills, bile brain. tended accumulate plasma a lesser extent Several (observed previously other organisms) also observed most tissues biofluids, including both saturated unsaturated fluorotelomer FTCA, FTUCA, 7:3 FTCA), perfluorooctanoic acid (PFOA). FTCA was major metabolite all tissues/biofluids, except bile, where PFOA occurred highest concentrations. Unexpectedly levels (up 3.7ng/g) detected Phase 2 metabolites, have been reported fish following exposure alcohols, not these experiments, probably due low abundance. Nevertheless, detection indicates that be an indirect route PFCAs