Impact of Nondigestible Oligosaccharides on Gut-Associated Lymphoid Tissue and Oral Tolerance Induction

摘要: Human milk is very rich in nondigestible oligosaccharides, which support colonization of Bifidobacteria and Lactobacilli immune maturation. Manufactured oligosaccharides are added to infant formula order mimic functional aspects human oligosaccharides. They the growth beneficial microbes reduce gastrointestinal respiratory infections. Furthermore they risk developing allergic disease when provided early life. Oral tolerance induction key prevention allergies. Environmental factors such as dietary constituents with commensal microorganisms at mucosal surface crucial for generation tolerance. Evidence building that galacto- fructo-oligosaccharides can either directly or indirectly modulate GALT systemic system health disease. Besides increasing IL-10 IgA mice human, were found induce regulatory T-cells spleens affected cow’s allergy. In addition, galectin-9 capable IgE neutralization. The immunologic basis by may affect discussed this book chapter.