The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease

摘要: Introduction: Epidemiological studies indicate that significant decreases in the incidence of Alzheimer’s disease (AD) may be obtained by targeting multiple middle-age risk factors. However, as dementia is unlikely to diagnosed for decades, short-term outcome measures are required. AD biomarker changes precede clinical symptoms many years, but their sensitivity mid-life change remains unknown. Methods and analysis: PREVENT a prospective cohort study examining status at least 150 individuals genetically high, medium or low late-onset AD. Participants children with without allocated lowrisk groups according parental ApoE genotype. The biomarkers examined over 2 years plasma CSF Aβ42 amyloid, Tau pTau, proinflammatory cytokines, acute-phase proteins, medial temporal-lobe atrophy, white matter lesion volume, cognitive performance related transentorhinal hippocampal functioning