CFP-1 interacts with HDAC1/2 complexes in C. elegans development
作者： Jonathan Joseph Biro , Bharat Pokhrel , Yannic Chen
DOI: 10.1101/451237
关键词:
摘要: Background: CFP-1 (CXXC finger binding protein 1) is an evolutionarily conserved that binds to non-methylated CpG-rich promoters in humans and C. elegans. This epigenetic regulator a part of the COMPASS complex contains H3K4me3 methyltransferase SET1 mammals SET-2 Previous studies have indicated importance cfp-1 embryonic stem cell differentiation fate specification. However, neither function nor mechanism action well understood at organismal level. Here we used cfp-1(tm6369) set-2(bn129) elegans mutant investigate gene induction development. Results: We characterised mutants found both set-2 play important role regulation fertility development organism. Furthermore, are required for H3K4 trimethylation repressive expression heat shock salt-inducible genes. Interestingly, but not genetically interacts with Histone Deacetylase (HDAC1/2) complexes regulate fertility, suggesting outside complex. Additionally acts on non-redundant pathways Conclusion: Our results suggest HDAC1/2 independent its within propose could cooperate and/or context dependent manner.
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