Rapid Change of Platelet Aggregability in Acute Hyperglycemia Detection by a Novel Laser-light Scattering Method

摘要: We examined the alteration of platelet aggregability in acute hyperglycemia during 75-gram oral glucose tolerance tests (OGTT). Twenty subjects underwent OGTT and venous blood samples were obtained before (0 min), 60, 120 180 min postload. Platelet shown as number small aggregates was measured with a novel laser-light scattering (LS) method. increased parallel both immuno-reactive insulin (IRI) levels. The mean at 60 (12.30 ± 1.10 X 10 4 ) significantly higher than one 0 (8.32 0.88 , p 0.001), (10.63 0.98 0.05) (8.28 0.84 0.001) (mean SEM). Small correlated positively plasma levels postload (r = 0.67, while not IRI. It might be important to suppress transient for preventing onset coronary syndromes that could closely related hyperaggregability.