Control at the cell center: the role of spindle poles in cytoskeletal organization and cell cycle regulation.

摘要: Microtubule organizing centres (MTOCs), which include fungal spindle pole bodies and centrosome in higher eukaryotes, are a structurally diverse group of organelles that share conserved role microtubule nucleation formation. However, recent studies propose the function MTOC components extends far beyond these established roles. Numerous cell cycle regulators, checkpoint proteins plus tip binding localize to MTOCs during cycle, suggesting serve as cellular scaffolds. In addition, several such gamma-tubulin its associating have been directly implicated control progression, activation responses regulation organization dynamics. Collectively, findings implicate centers coordinate events at both minus ends with cycle. this review, we discuss support for components, particular gamma-tubulin, response coordination