Arginine and immune function.

摘要: : L-Arginine (Arg) was traditionally classified as a nutritionally non-essential amino acid for infant and adult humans; however, it is now known that besides serving building block protein, plays an essential role in the functions of immune system. Arg physiological substrate synthesis nitric oxide (NO), which key mediator responses. Additionally, emerging evidence shows exerts regulatory signal transduction pathways involving mammalian (or mechanistic) targets rapamycin specific mitogen-activated protein kinases immunocytes, thereby affecting immunity. Because high requirements multiple metabolic pathways, dietary supplementation may be necessary strategy to maintain homeostasis good health body under many pathological conditions. Much experimental clinical data support notion nutrient both innate adaptive systems humans other animals. An important outcome this research availability Arg- supplemented foods feed-grade livestock species. Future studies are needed address safety issue chronic mammals so fully realize benefits functional acid.