Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study

摘要: Summary Background No clear epidemiological hereditary effects of radiation exposure in human beings have been reported. However, no previous studies investigated mortality into middle age a population whose parents were exposed to substantial amounts before conception. We assessed children the atomic bomb survivors after 62 years follow-up. Methods In this prospective cohort study, we 75 327 singleton Hiroshima and Nagasaki unexposed controls, born between 1946 1984, followed up Dec 31, 2009. Parental gonadal doses from bombings primary exposures. The endpoint was death due cancer or non-cancer disease, based on certificates. Findings Median follow-up 54·3 (IQR 45·4–59·3). 5183 participants died disease. mean 68 689 surviving at end 53·1 (SD 7·9) with 15 623 (23%) older than 60 years. For who non-zero dose radiation, 264 mGy 463). detected association maternal risk caused by (hazard ratio [HR] for 1 Gy change 0·891 [95% CI 0·693–1·145]; p=0·36) diseases (0·973 [0·849–1·115]; p=0·69). Likewise, paternal had effect deaths (0·815 [0·614–1·083]; p=0·14) disease (1·103 [0·979–1·241]; p=0·12). Age time parental delivery death. Interpretation Late ionising include increased risks, models transgenerational predict more genetic people radiation. bombs indications deleterious health Epidemiological complemented sensitive molecular techniques are needed understand overall preconception beings. Funding Japanese Ministry Health, Labour Welfare, US Department Energy.