ELEVATION IN RAT BRAIN HISTAMINE CONTENT AFTER FOCUSED MICROWAVE IRRADIATION
作者： Lindsay B. Hough , Edward F. Domino
DOI: 10.1111/J.1471-4159.1977.TB09609.X
关键词:
摘要: Microwave irradiation focused on the head of small rodents is now widely used as a means more accurately measuring acetylcholine, choline, cyclic AMP, and several other important brain constituents. Because its probable neurotransmitter role rapid turnover, similar approach was taken to study histamine. Histamine measured by modified radio-enzymatic method found be nearly tripled in brains from microwave treated rats, compared decapitation controls (124 vs 42 ng/g). Possible explanations include microwave-induced inactivation histamine breakdown, redistribution previously unmeasured histamine, microwave- induced histidine decarboxylation. Brain remained unchanged up 30 min after heated decapitated rats also had elevated levels, indicating that levels do not represent remainder rapidly depleting pool. No evidence for found. Furthermore, did enhance formation (3H)histamine intraventricular C3H)histidine administration, lack It concluded elevation rat probably artifactual, although mechanism responsible this phenomenon remains obscure.
sci-hub.se 参考文章(15)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Jean-Charles Schwartz, Hélène Pollard, Serge Bischoff, TURNOVER OF HISTAMINE IN RAT BRAIN AND ITS DECREASE UNDER BARBITURATE ANESTHESIA Journal of Pharmacology and Experimental Therapeutics. ,vol. 190, pp. 88- 99 ,(1974)
Julius Axelord, Solomon H. Snyder, Hugo Bauer, THE FATE OF C14-HISTAMINE IN ANIMAL TISSUES Journal of Pharmacology and Experimental Therapeutics. ,vol. 144, pp. 373- 379 ,(1964)
A. Guidotti, D.L. Cheney, M. Trabucchi, M. Doteuchi, C. Wang, R.A. Hawkins, Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology Neuropharmacology. ,vol. 13, pp. 1115- 1122 ,(1974) , 10.1016/0028-3908(74)90061-6
Malcolm N. Blumenthal, Beatrice Roitman, Gary Carlson, Lloyd Fish, Isotope assay of histamine release Biochemical Medicine. ,vol. 11, pp. 312- 317 ,(1974) , 10.1016/0006-2944(74)90129-X
Floris de Balbian Verster, C.Allen Robinson, Carol A. Hengeveld, Elaine S. Bush, Freehand cerebroventricular injection technique for unanesthetized rats Life Sciences. ,vol. 10, pp. 1395- 1402 ,(1971) , 10.1016/0024-3205(71)90268-2
Cyril O. Enwonwu, Bonnie S. Worthington, ELEVATION OF BRAIN HISTAMINE CONTENT IN PROTEIN-DEFICIENT RATS Journal of Neurochemistry. ,vol. 24, pp. 941- 945 ,(1975) , 10.1111/J.1471-4159.1975.TB03659.X
Michael A. Beaven, Sten Jacobsen, Zdenka Horáková, Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine Clinica Chimica Acta. ,vol. 37, pp. 91- 103 ,(1972) , 10.1016/0009-8981(72)90419-6
D.L. Richardson, C.L. Scudder, Microwave irradiation and brain γ-aminobutyric acid levels in mice Life Sciences. ,vol. 18, pp. 1431- 1439 ,(1976) , 10.1016/0024-3205(76)90360-X
Key Dismukes, Solomon H. Snyder, Histamine turnover in rat brain. Brain Research. ,vol. 78, pp. 467- 481 ,(1974) , 10.1016/0006-8993(74)90929-9