Palladium-catalyzed three-component cascade arylthiolation with aryldiazonium salts as S-arylation sources
作者： Jianxiao Li , Hao Tang , Zidong Lin , Shaorong Yang , Wanqing Wu
DOI: 10.1039/D0OB00828A
关键词:
摘要: A novel and efficient palladium-catalyzed three-component cascade cyclization/arylthiolation has been developed for the assembly of diverse 3-sulfenylindole 3-sulfenylbenzofuran derivatives from 2-alkynylamines 2-alkynylphenols, aryldiazonium salts, Na2S2O3 under aerobic conditions with PEG-200 as an environmentally benign medium. The current study features exceptional functional group tolerance without additional ligands, oxidants or silver eco-friendly mild reaction conditions. ionic liquid [C2OHmim]Cl plays a crucial role in this protocol friendly additive. Notably, procedure represents first example use salts direct S-arylation sources type chemical transformation.
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