Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy Study.

摘要: Background— Arrhythmia risk stratification with regard to prophylactic implantable cardioverter-defibrillator therapy is a completely unsolved issue in idiopathic dilated cardiomyopathy (IDC). Methods and Results— was performed prospectively 343 patients IDC, including analysis of left ventricular (LV) ejection fraction size by echocardiography, signal-averaged ECG, arrhythmias on Holter QTc dispersion, heart rate variability, baroreflex sensitivity, microvolt T-wave alternans. During 52±21 months follow-up, major arrhythmic events, defined as sustained tachycardia, fibrillation, or sudden death, occurred 46 (13%). On multivariate analysis, LV the only significant arrhythmia predictor sinus rhythm, relative 2.3 per 10% decrease (95% CI, 1.5 3.3; P=0.0001). Nonsustained tachycardia associated trend towa...