PON1 and Organophosphate Toxicity
作者： Lucio G. Costa , Wan-Fen Li , Rebecca J. Richter , Diana M. Shih , Aldons J. Lusis
DOI: 10.1007/978-1-4615-1027-7_8
关键词:
摘要: Early studies on different human populations showed that the hydrolytic activity of serum paraoxonase (PON1) was polymorphically distributed, raising hypothesis individuals with low PON1 may be at higher risk from toxic effects due to exposure organophosphorus (OP) insecticides. Evidence this case has been obtained a number animal studies. First, species (e.g. birds) are especially sensitive OP toxicity. Among mammals, rabbits, which have high activity, more resistant toxicity than rats. Second, injection purified into rats and mice protects them against acute various OPs. Third, knockout wild type animals oxygen analogs OPs, such as chlorpyrifos oxon diazoxon, resistance can restored by injecting PON1. Surprisingly, null do not show an increased sensitivity paraoxon, substrate after named. In vitro catalytic efficiency PON1, assayed physiological conditions, indicated relevant for detoxication, hence influence toxicity, some OPs oxon, diazoxon), but paraoxon. The young animals, possibly children, explained in cases oxon) activity.
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