Evidence for non-additive influence of single nucleotide polymorphisms within the apolipoprotein E gene.

摘要: Summary We analyzed 13 single nucleotide polymorphisms (SNPs) within the apolipoprotein E (APOE) gene, to identify pairs of SNPs that interact in a non-additive manner influence genotypic mean levels ApoE protein blood. An overparameterized general linear model two-SNP genotype means was applied data from 456 female and 398 male unrelated European Americans Rochester, MN, USA. We found statistically significant evidence for non-additivity between sample, but not sample. observed nine with at α= 0.05 level statistical significance when approximately three were expected by chance. Five involved (560, 624 1163) did have considered separately single-site analysis. Three involving four (832, 1998, 3937 4951) showed least one two other samples Jackson, MS, USA North Karelia, Finland. Although all these had Rochester separately, only SNP gave result samples. The are located promoter, intronic exonic regions, 3' polyadenylation signal APOE gene. Our study suggests analyses consider exons ignore contexts such as those indexed gender population, disregard effects, may inappropriately contribution gene genetic architecture trait has complex multifactorial etiology.