Postsynaptic plasticity of GABAergic synapses.

摘要: The flexibility of neuronal networks is believed to rely mainly on the plasticity excitatory synapses. However, like their counterparts, inhibitory synapses also undergo several forms synaptic plasticity. This review examines recent advances in understanding molecular mechanisms leading postsynaptic GABAergic Specifically, modulation GABAA receptor (GABAAR) number at sites plays a key role, with interaction GABAARs scaffold protein gephyrin and other scaffold/regulatory proteins having particular importance. Our these interactions are progressing, based insights into processes GABAAR lateral diffusion, dynamics, nanoscale organization. article part special issue entitled 'Mobility trafficking membrane proteins'.