Prognostic value of carbohydrate antigen125 and carcino embryonic antigen expression in patients with colorectal carcinoma and its guiding significance for chemotherapy.

摘要: The aim of this study is to evaluate the predictive value carbohydrate antigen125 (CA125) and carcino embryonic antigen (CEA) expression its guiding role choosing chemotherapy regimen in post-operation patients with colorectal carcinoma.The clinical data all patients, including laboratory pathological data, were collected from electronic medical records. Kaplan-Meier Log rank test, COX regression model subgroup analyses employed assess correlation between CA125 CEA carcinoma survival, effect on efficacy.Kaplan-Meier showed that negatively related progression-free survival (PFS) post-operative Median PFS was 1140 days high expression, 1387 low (χ = 4.715, P .030); also associated 1197 1424 4.992, .025). Subgroup analysis normal had better prognosis, median 1505 days, (or) poor prognosis 1162 13.346, .001), found there no statistical difference oxaliplatin plus capecitabine (XELOX) oxaliplatin, 5-fluorouracil Calcium folinate (FOLFOX) expression. However, these or (and) treated XELOX 1082 FOLFOX 1335 4.547, .033).Expression have some significance for cancer after operation; Compared XELOX, more effective carcinoma.