Regional Myocardial Perfusion After Experimental Subarachnoid Hemorrhage

摘要: Background and Purpose—The pathophysiology of cardiac injury after subarachnoid hemorrhage (SAH) remains controversial. Data from animal models suggest that catecholamine-mediated is the most likely cause SAH. However, researchers also have proposed myocardial ischemia to be underlying cause, as a result coronary artery disease, spasm, or hypertension tachycardia. To test hypothesis SAH-induced occurs in absence hypoperfusion, we developed an experimental canine model reproduces clinical pathological lesions SAH defines epicardial microvascular circulation. Methods—Serial ECG, hemodynamic measurements, angiography, regional blood flow measurements by radiolabeled microspheres, 2D echocardiography, contrast echocardiography were performed 9 dogs with 5 controls. Results—Regional wall motion abnormalities w...