Extracellular Signals and Transduction Mechanisms Controlling the Adenosine Transport in Neural Cells

摘要: The adenosine transport in bovine chromaffin cells is highly regulated by different extracellular signals, both at short and long-term. short-term regulation signals such as secretagogues or direct activation of protein kinases A C inhibit the capacity. Binding studies with nitrobenzylthioinosine show that inhibition runs parallel a decrease number binding sites for this ligand. mediated phosphorylation-dephosphorylation process. Extracellular bind o nuclear receptors are responsible long-term regulation. Thyroid hormones increase increasing transporters plasma membrane level. This requires protein-synthesizing mchanism. On contrary, dexamethasone retinoic acid transpor capacity revert action thyroid hormones.