LncRNA PVT1 promotes cervical cancer progression by sponging miR-503 to upregulate ARL2 expression.

摘要: Cervical cancer (CC) is a huge threat to the health of women worldwide. Long non-coding RNA plasmacytoma variant translocation 1 gene (PVT1) was proved be associated with development diverse human cancers, including CC. Nevertheless, exact mechanism PVT1 in CC progression remains unclear. Levels PVT1, microRNA-503 (miR-503), and ADP ribosylation factor-like protein 2 (ARL2) were measured by quantitative reverse transcription-polymerase chain reaction or western blot assay. 3-(4,5)-Dimethylthiazole-2-y1)-2,5-biphenyl tetrazolium bromide (MTT) flow cytometry used examine cell viability apoptosis, respectively. For migration invasion detection, transwell assay performed. The interaction between miR-503 ARL2 shown dual luciferase reporter A nude mouse model constructed clarify role vivo. expressions increased, whereas expression decreased tissues cells. sponge miR-503, targeted ARL2. knockdown suppressed proliferation, migration, cells, which could largely reverted inhibitor. In addition, upregulated attenuate si-PVT1-mediated anti-proliferation anti-metastasis effects on Silenced also inhibited tumor growth exerted suppressor via miR-503/ARL2 axis, at least part.