Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits.

摘要: Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is crucial for reward-based learning action control. While dopamine has been extensively investigated in this context, synaptic effects serotonin (5-HT) have largely unexplored. Here, we how serotonergic signaling affects associative plasticity at glutamatergic synapses on striatal projection neurons direct pathway (dSPNs). Combining chemogenetic optogenetic approaches reveals that impeding preferentially gates spike-timing-dependent long-term depression (t-LTD) thalamostriatal synapses. This t-LTD requires dampened activity 5-HT4 receptor subtype, which demonstrate controls dendritic Ca2+ signals by regulating BK channel activity, localizes shaft. The 5-HT provide insights into changes levels associated with behavioral states or pathology affect striatal-dependent processes.