Ribonucleotide reductase genes of Bacillus prophages: a refuge to introns and intein coding sequences
作者： V. Lazarevic
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摘要: The ribonucleotide reductase gene tandem bnrdE/ bnrdF in SPβ-related prophages of different Bacillus spp. isolates presents configurations intervening sequences, comprising one to three six non-homologous splicing elements. Insertion sites group I introns and intein DNA are clustered relatively short segments encoding functionally important domains the reductase. Comparison bnrdE homologs reveals mutual exclusion a intron an coding sequence flanking codon that specifies conserved cysteine. In vivo was demonstrated for all introns. However, two them part mRNA precursor molecules remains unspliced. Intergenic bnrdE–bnrdF regions unexpectedly long, between 238 541 nt. longest encodes putative polypeptide related HNH homing endonucleases.
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