Design of Lipid Matrix Particles for Fenofibrate: Effect of Polymorphism of Glycerol Monostearate on Drug Incorporation and Release
作者： Dengning Xia , Fude Cui , Yong Gan , Huiling Mu , Mingshi Yang
DOI: 10.1002/JPS.23830
关键词:
摘要: The effect of polymorphism glycerol monostearate (GMS) on drug incorporation and release from lipid matrix particles (LMPs) was investigated using fenofibrate as a model drug. X-ray powder diffraction differential scanning calorimetry were used to study the change GMS in matrix. When medium-chain triglycerides (MCT) absent, melted frozen α-form with molecularly dispersed, whereas β-form formed part crystallized out when ratio GMS/MCT 2:1 (w/w). For LMP composed (2:1, w/w) prepared, nanometer range, micrometer range. dispread nanoparticles, expulsed microparticles because denser crystalline packing than GMS, caused faster that nanoparticles. During storage, transformation into more stable promoted expulsion precipitation. In conclusion, is an important factor determining particle stability, incorporation, LMP. Critical attention should be paid investigation well control formulating lipid-based particles.
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